Category Filter
- Advanced Imaging
- Behavioral Health
- Chronic Condition Management
- Genetic Testing
- Hemophilia Drugs
- Medical Oncology Regimen Program
- Medical Policies
- Pre-Service Review (Precertification/Predetermination)
- Provider-Administered Drug Policies
- Radiation Therapy
- Self-Administered Drug Policies
- Transgender Services
Asset Publisher
Kyprolis® (carfilzomib)
Policy Number: VP-0157
Intravenous
Last Review Date: 05/02/2024
Date of Origin: 02/07/2013
Dates Reviewed: 12/2013, 02/2014, 06/2014, 09/2014, 12/2014, 05/2015, 08/2015, 11/2015, 02/2016, 05/2016, 08/2016, 11/2016, 02/2017, 05/2017, 08/2017, 11/2017, 02/2018, 05/2018, 09/2018, 12/2018, 03/2019, 06/2019, 09/2019, 12/2019, 03/2020, 06/2020, 09/2020, 12/2020, 03/2021, 06/2021, 09/2021, 12/2021, 03/2022, 06/2022, 09/2022, 12/2022, 03/2023, 06/2023, 09/2023, 12/2023, 03/2024, 05/2024
FOR PEEHIP Members Only -Coverage excludes the provider-administered medication(s) outlined in this drug policy from being accessed through a specialty pharmacy. It must be obtained through buy and bill. |
- Length of Authorization 1,5,21,32,36
Coverage will be provided for 6 months and may be renewed (unless otherwise specified).
Multiple Myeloma
- Combination therapy with daratumumab, lenalidomide, and dexamethasone is limited to eight (8) 28-day treatment cycles.
- Combination therapy with lenalidomide as maintenance therapy is limited to a maximum of 2 years of treatment.
Waldenström’s Macroglobulinemia/Lymphoplasmacytic Lymphoma
- Combination therapy with rituximab and dexamethasone (CaRD regimen) is limited to six (6) 21-day induction treatment cycles and eight (8) 56-day maintenance treatment cycles.
- Dosing Limits
- Quantity Limit (max daily dose) [NDC Unit]:
- Kyprolis 10 mg single-dose vial: 2 vials per 28-day cycle
- Kyprolis 30 mg single-dose vial: 1 vial per 28-day cycle
- Kyprolis 60 mg single-dose vial: 12 vials per 28-day cycle
- Max Units (per dose and over time) [HCPCS Unit]:
- Multiple Myeloma
- 720 billable units (720 mg) every 28 days
- Systemic Light Chain Amyloidosis
- 480 billable units (480 mg) every 28 days
- Waldenström’s Macroglobulinemia/Lymphoplasmacytic Lymphoma
- 320 billable units (320 mg) every 21 days
- Multiple Myeloma
- Initial Approval Criteria 1
Coverage is provided in the following conditions:
- Patient is at least 18 years of age; AND
Multiple Myeloma † ‡ Ф 1,2,7,9-11,13-17,19,20,22-29,32-37,39
- Used as primary therapy for symptomatic disease; AND
- Used in combination with daratumumab, lenalidomide, and dexamethasone (transplant candidates ONLY); OR
- Used in combination with lenalidomide and dexamethasone; OR
- Used in combination with dexamethasone and cyclophosphamide; OR
- Used for disease relapse after 6 months following primary induction therapy with the same regimen; AND
- Used in combination with lenalidomide and dexamethasone; OR
- Used in combination with dexamethasone and cyclophosphamide; OR
- Used for relapsed or refractory disease after 3 prior therapies; AND
- Used in combination with bendamustine and dexamethasone; OR
- Used for previously treated relapsed, progressive, or refractory disease; AND
- Used as a single agent †; OR
- Used in combination with one of the following regimens:
- Dexamethasone with or without lenalidomide †
- Dexamethasone and daratumumab †
- Dexamethasone and daratumumab and hyaluronidase-fihj †
- Dexamethasone and cyclophosphamide with or without thalidomide
- Dexamethasone and isatuximab-irfc †
- Dexamethasone and selinexor
- Dexamethasone and pomalidomide
- Dexamethasone and venetoclax (patients with t(11:14) ONLY); OR
- Used as maintenance therapy for symptomatic disease in transplant candidates; AND
- Used in combination with lenalidomide; AND
- Used after response to primary myeloma therapy; OR
- Used for response or stable disease following an autologous hematopoietic cell transplant (HCT); OR
- Used for response or stable disease following a tandem autologous or allogeneic HCT for high risk* patients
- Used in combination with lenalidomide; AND
- Used as maintenance therapy for symptomatic disease in transplant candidates; AND
*High-risk as defined by the Revised International Staging System for Multiple Myeloma is the presence of del(17p) and/or translocation t(4;14) and/or translocation t(14;16). This is not an all-inclusive list. Refer to the NCCN Multiple Myeloma Guidelines for additional risk factors.
Waldenström’s Macroglobulinemia/Lymphoplasmacytic Lymphoma ‡ 2,5,18,21
- Used in combination with rituximab and dexamethasone (CaRD regimen); AND
- Used as primary therapy; OR
- Used for relapsed disease; AND
-
-
- CaRD regimen was previously used as primary therapy; AND
-
- Patient had a prolonged response (i.e., 24 months) to CaRD therapy
Systemic Light Chain Amyloidosis ‡ 2,30,31,38
- Patient has newly diagnosed disease; AND
- Used in combination with dexamethasone; AND
- Patient has significant neuropathy; OR
- Patient has relapsed or refractory disease; AND
- Patient has non-cardiac disease; AND
- Used as a single agent; OR
- Used in combination with dexamethasone; OR
- Patient has significant neuropathy; AND
- Used as repeat of initial therapy if relapse-free for several years; AND
- Used in combination with dexamethasone
† FDA Approved Indication(s); ‡ Compendia Recommended Indication(s); Ф Orphan Drug
- Renewal Criteria 1,2
Coverage may be renewed based upon the following criteria:
- Patient continues to meet the indication-specific relevant criteria such as concomitant therapy requirements (not including prerequisite therapy), performance status, etc. identified in section III; AND
- Disease response with treatment as defined by stabilization of disease or decrease in size of tumor or tumor spread; AND
- Absence of unacceptable toxicity from the drug. Examples of unacceptable toxicity include: cardiac toxicity (e.g., CHF, pulmonary edema, decreased ejection fraction, cardiomyopathy, myocardial ischemia, myocardial infarction, etc.), pulmonary toxicity (e.g., acute respiratory distress syndrome [ARDS], acute respiratory failure, etc.), pulmonary hypertension, dyspnea, severe infusion-related reactions, tumor lysis syndrome (TLS), thrombocytopenia, hepatic toxicity/failure, thrombotic microangiopathy (e.g., thrombotic thrombocytopenic purpura/hemolytic uremic syndrome [TTP/HUS], etc.), acute renal failure, severe hypertension, posterior reversible encephalopathy syndrome (PRES), venous thromboembolic events (e.g., deep venous thrombosis, pulmonary embolism, etc.), hemorrhage, progressive multifocal leukoencephalopathy (PML), etc.; AND
Multiple Myeloma 32
- Combination therapy with daratumumab, lenalidomide, and dexamethasone may be renewed up to a maximum of eight (8) 28-day treatment cycles.
Multiple Myeloma (maintenance therapy in combination with lenalidomide) 36
- Refer to Section III for criteria; AND
- Combination therapy with lenalidomide as maintenance therapy may be renewed up to a maximum of 2 years of therapy
Waldenström’s Macroglobulinemia/Lymphoplasmacytic Lymphoma 5,21
- Combination therapy with rituximab and dexamethasone (CaRD regimen) may be renewed up to a maximum of six (6) 21-day induction treatment cycles and eight (8) 56-day maintenance treatment cycles.
- Dosage/Administration 1,5,7,9,12,20-22,24-28,30,32-36,38-40
Indication |
Dose* |
Multiple Myeloma (primary therapy OR disease relapse ≥6 months following primary induction therapy with the same regimen) |
Combination with daratumumab, lenalidomide and dexamethasone (Dara-KRd) 20/56 regimen:
Combination with lenalidomide and dexamethasone (KRd) 20/36 regimen:
May proceed to maintenance therapy in combination with lenalidomide for up to 2 years. Combination with cyclophosphamide and dexamethasone (KCd) 20/36 regimen:
20/70 regimen:
|
Multiple Myeloma (relapsed, progressive, or refractory disease) |
Single agent 20/27 regimen:
20/56 regimen:
Combination with lenalidomide and dexamethasone (KRd) 20/27 regimen:
Combination with dexamethasone (Kd) 20/56 regimen:
20/70 regimen:
Combination with daratumumab (or daratumumab and hyaluronidase-fihj) and dexamethasone (DKd) 20/56 regimen:
20/70 regimen:
Combination with cyclophosphamide, thalidomide, and dexamethasone 20/36 regimen:
Combination with cyclophosphamide and dexamethasone (KCd) 20/36 regimen: Induction
Maintenance
Combination with isatuximab-irfc and dexamethasone (Isa-Kd) 20/56 regimen:
Combination with selinexor and dexamethasone (XKd) 20/56 regimen:
Combination with pomalidomide and dexamethasone(KPd) 20/27 regimen:
20/36 regimen:
Combination with venetoclax and dexamethasone 20/27 regimen:
20/56 regimen:
treatment cycle
20/70 regimen:
|
Multiple Myeloma (relapsed or refractory disease after 3 prior therapies) |
Combination with bendamustine and dexamethasone 20/27 regimen:
|
Multiple Myeloma (maintenance therapy |
Combination with lenalidomide
|
CaRD regimen (carfilzomib, rituximab, dexamethasone) Induction
Maintenance
|
|
Systemic Light Chain Amyloidosis |
Single agent or combination with dexamethasone 20/27/56 regimen
20/36 regimen
|
*Note: For patients with body surface area (BSA) of 2.2 m2 or less, calculate the Kyprolis dose using actual BSA. Dose adjustments do not need to be made for weight changes of 20% or less. For patients with a BSA greater than 2.2 m2, calculate the Kyprolis dose using a BSA of 2.2 m2. |
- Billing Code/Availability Information
HCPCS Code:
- J9047 – Injection, carfilzomib, 1 mg; 1mg = 1 billable unit
NDC(s):
- Kyprolis 10 mg single-dose vial for injection: 76075-0103-xx
- Kyprolis 30 mg single-dose vial for injection: 76075-0102-xx
- Kyprolis 60 mg single-dose vial for injection: 76075-0101-xx
- References
- Kyprolis [package insert]. Thousand Oaks, CA; Onyx Pharmaceuticals, Inc.; June 2022. Accessed January 2024.
- Referenced with permission from the NCCN Drugs & Biologics Compendium (NCCN Compendium®) for Carfilzomib. National Comprehensive Cancer Network, 2024. The NCCN Compendium® is a derivative work of the NCCN Guidelines®. NATIONAL COMPREHENSIVE CANCER NETWORK®, NCCN®, and NCCN GUIDELINES® are trademarks owned by the National Comprehensive Cancer Network, Inc. To view the most recent and complete version of the Compendium, go online to NCCN.org. Accessed January 2024.
- BGM Durie, J-L Harousseau, J S Miguel, et al on behalf of the International Myeloma Working Group. International uniform response criteria for multiple myeloma. Leukemia. 2006 Sep; 20(9):1467-73.
- Dimopoulos MA, Kastritis E, Owen RG, et al. Treatment recommendations for patients with Waldenström’s macroglobulinemia (WM) and related disorders: IWWM-7 consensus. Blood. 2014; 124(9):1404–1411.
- Treon SP, Tripsas CK, Meid K, et al. Carfilzomib, rituximab, and dexamethasone (CaRD) treatment offers a neuropathy-sparing approach for treating Waldenström’s macroglobulinemia. Blood. 2014;124(4):503–510.
- UpToDate. Hudson (OH): Lexicomp Inc.: Carfilzomib: Drug information. Topic 86042 Version 270.0, 2024 Accessed February 2024.
- Shah JJ, Stadtmauer EA, Abonour R, et al. Carfilzomib, pomalidomide and dexamethasone for relapsed or refractory myeloma. Blood 2015; 126: 2284-2290.
- Berdeja JG, Hart LL, Mace JR, et al. Phase I/II study of the combination of panobinostat and carfilzomib in patients with relapsed/refractory multiple myeloma. Haematologica 2015; 100: 670-676.
- Bringhen S, Petrucci MT, Larocca A, et al. Carfilzomib, cyclophosphamide, and dexamethasone in patients with newly diagnosed multiple myeloma: a multicenter, phase 2 study. Blood. 2014 Jul 3;124(1):63-9.
- Moreau P, Mateos MV, Berenson JR, et al. Once weekly versus twice weekly carfilzomib dosing in patients with relapsed and refractory multiple myeloma (A.R.R.O.W.): interim analysis results of a randomised, phase 3 study. Lancet Oncol 2018;19(7):953-964.
- Chari A, Martinez-Lopez J, Mateos MV, et al. Daratumumab plus carfilzomib and dexamethasone in patients with relapsed or refractory multiple myeloma. Blood 2019. Aug 1;134(5):421-431. Doi: 10.1182/blood.2019000722. Epub 2019 May 21.
- Mikhael JR, Reeder CB, Libby EN, et al. Phase Ib/II trial of CYKLONE (cyclophosphamide, carfilzomib, thalidomide and dexamethasone) for newly diagnosed myeloma. Br J Haematol. 2015 Apr; 169(2): 219–227. Published online 2015 Feb 13.
- Stewart AK, Rajkumar SV, Dimopoulos MA, et al. Carfilzomib, lenalidomide, and dexamethasone for relapsed multiple myeloma. N Engl J Med. 2015 Jan 8;372(2):142-52. Doi: 10.1056/NEJMoa1411321. Epub 2014 Dec 6.
- Dimopoulos MA, Moreau P, Palumbo A, et al. Carfilzomib and dexamethasone versus bortezomib and dexamethasone for patients with relapsed or refractory multiple myeloma (ENDEAVOR): a randomised, phase 3, open-label, multicentre study. Lancet Oncol. 2016 Jan;17(1):27-38. Doi: 10.1016/S1470-2045(15)00464-7. Epub 2015 Dec 5.
- Papadopoulos KP, Siegel DS, Vesole DH, et al. Phase I study of 30-minute infusion of carfilzomib as single agent or in combination with low-dose dexamethasone in patients with relapsed and/or refractory multiple myeloma. J Clin Oncol. 2015 Mar 1;33(7):732-9. Doi: 10.1200/JCO.2013.52.3522. Epub 2014 Sep 15.
- Siegel DS, Martin T, Wang M, et al. A phase 2 study of single-agent carfilzomib (PX-171-003-A1) in patients with relapsed and refractory multiple myeloma. Blood. 2012 Oct 4;120(14):2817-25. Doi: 10.1182/blood-2012-05-425934. Epub 2012 Jul 25.
- Vij R, Wang M, Kaufman JL, et al. An open-label, single-arm, phase 2 (PX-171-004) study of single-agent carfilzomib in bortezomib-naive patients with relapsed and/or refractory multiple myeloma. Blood. 2012 Jun 14;119(24):5661-70. Doi: 10.1182/blood-2012-03-414359. Epub 2012 May 3.
- Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Waldenström Macroglobulinemia/Lymphoplasmacytic Lymphoma, Version 2.2024. National Comprehensive Cancer Network, 2024. NATIONAL COMPREHENSIVE CANCER NETWORK®, NCCN®, and NCCN GUIDELINES® are trademarks owned by the National Comprehensive Cancer Network, Inc. To view the most recent and complete version of the Guidelines, go online to NCCN.org. Accessed February 2024.
- Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Multiple Myeloma, Version 2.2024. National Comprehensive Cancer Network, 2024. NATIONAL COMPREHENSIVE CANCER NETWORK®, NCCN®, and NCCN GUIDELINES® are trademarks owned by the National Comprehensive Cancer Network, Inc. To view the most recent and complete version of the Guidelines, go online to NCCN.org. Accessed January 2024.
- Rosenbaum CA, Stephens LA, Kukreti V, et al. Phase 1/2 study of carfilzomib, pomalidomide, and dexamethasone (KPd) in patients (Pts) with relapsed/refractory multiple myeloma (RRMM): A Multiple Myeloma Research Consortium multicenter study. DOI: 10.1200/JCO.2016.34.15_suppl.8007 Journal of Clinical Oncology 34, no. 15_suppl (May 20, 2016) 8007-8007.
- Meid K, Dubeau T, Severns P, et al. Long-Term Follow-up of a Prospective Clinical Trial of Carfilzomib, Rituximab and Dexamethasone (CaRD) in Waldenstrom’s Macroglobulinemia. Blood 2017; 130:2772-2772.
- Yong K, Brown S, Hinsley S, et al. Carfilzomib, cyclophosphamide and dexamethasone is well tolerated in patients with relapsed/refractory multiple myeloma who have received one prior regimen. 2015; 126:1840.
- Dimopoulos M, Quach H, Mateos MV, et al. Carfilzomib, dexamethasone, and daratumumab versus carfilzomib and dexamethasone for patients with relapsed or refractory multiple myeloma (CANDOR): results from a randomised, multicentre, open-label, phase 3 study. Lancet. 2020;396(10245):186-197.
- Jakubowiak AJ, Dytfeld D, Griffith KA, et al. A phase 1/2 study of carfilzomib in combination with lenalidomide and low-dose dexamethasone as a frontline treatment for multiple myeloma. Blood. 2012 Aug 30;120(9):1801-9.
- Korde N, Zingone A, Kwok M, et al. Phase II Clinical and Correlative Study of Carfilzomib, Lenalidomide, and Dexamethasone (CRd) in Newly Diagnosed Multiple Myeloma (MM) Patients. Blood. 2012 Nov 12;120(21):732.
- Korde N, Zingone A, Kwok ML, et al. Phase II Clinical and Correlative Study Of Carfilzomib, Lenalidomide, and Dexamethasone Followed By Lenalidomide Extended Dosing (CRD-R) Induces High Rates Of MRD Negativity In Newly Diagnosed Multiple Myeloma (MM) Patients. Blood. 2013. Nov 15;122(21):538.
- Zimmerman T, Raje NS, Reece D, et al. Final Results of a Phase 2 Trial of Extended Treatment (tx) with Carfilzomib (CFZ), Lenalidomide (LEN), and Dexamethasone (KRd) Plus Autologous Stem Cell Transplantation (ASCT) in Newly Diagnosed Multiple Myeloma (NDMM). Blood. 2016 Dec 2;128(22):675.
- Yong K, Hinsley S, De Tute, RM, et al. Maintenance with Carfilzomib Following Carfilzomib, Cyclophosphamide and Dexamethasone at First Relapse or Primary Refractory Multiple Myeloma (MM) on the Phase 2 Muk Five Study: Effect on Minimal Residual Disease. Blood. 2018 Nov 29;132(1):802.
- Moreau P, Dimopoulos MA, Yong K, et al. Isatuximab plus carfilzomib/dexamethasone versus carfilzomib/dexamethasone in patients with relapsed/refractory multiple myeloma: IKEMA Phase III study design. Future Oncol. 2020 Jan;16(2):4347-4358. Doi: 10.2217/fon-2019-0431.
- Manwani R, Mahmood S, Sachchithanantham S, et al. Carfilzomib is an effective upfront treatment in AL amyloidosis patients with peripheral and autonomic neuropathy. Br J Haematol 2019 Dec;187(5):638-641.doi: 10.1111/bjh.16122. Epub 2019 Aug 6.
- Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Systemic Light Chain Amyloidosis, Version 2.2024. National Comprehensive Cancer Network, 2024. NATIONAL COMPREHENSIVE CANCER NETWORK®, NCCN®, and NCCN GUIDELINES® are trademarks owned by the National Comprehensive Cancer Network, Inc. To view the most recent and complete version of the Guidelines, go online to NCCN.org. Accessed February 2024.
- Landgren O, Hulcrantz M, Diamond B, et al. Safety and Effectiveness of Weekly Carfilzomib, Lenalidomide, Dexamethasone, and Daratumumab Combination Therapy for Patients With Newly Diagnosed Multiple Myeloma: The MANHATTAN Nonrandomized Clinical Trial. JAMA Oncol. 2021 Jun 1;7(6):862-868. Doi: 10.1001/jamaoncol.2021.0611.
- Bringhen S, D’Agostino M, De Paoli L, et al. Phase 1/2 study of weekly carfilzomib, cyclophosphamide, dexamethasone in newly diagnosed transplant-ineligible myeloma. Leukemia. 2018 Apr;32(4):979-985. Doi: 10.1038/leu.2017.327.
- Gasparetto C, Lipe B, Tuchman S, et al. Once weekly selinexor, carfilzomib, and dexamethasone (SKd) in patients with relapsed/refractory multiple myeloma (MM). DOI: 10.1200/JCO.2020.38.15_suppl.8530 Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020) 8530-8530.
- Gay F, Günther A, Offidani M, et al. Carfilzomib, bendamustine, and dexamethasone in patients with advanced multiple myeloma: The EMN09 phase 1/2 study of the European Myeloma Network. Cancer. 2021 Sep 15;127(18):3413-3421. Doi: 10.1002/cncr.33647
- Gay F, Musto P, Scalabrini D, et al. Carfilzomib with cyclophosphamide and dexamethasone or lenalidomide and dexamethasone plus autologous transplantation or carfilzomib plus lenalidomide and dexamethasone, followed by maintenance with carfilzomib plus lenalidomide or lenalidomide alone for patients with newly diagnosed multiple myeloma (FORTE): a randomized, open-label, phase 2 trial. Lancet Oncol. 2021 Dec;22(12):1705-1720. Doi: 10.1016/S1470-2045(21)00535-0. Epub 2021 Nov 11.
- Moreau P, Dimopoulos MA, Mikhael J, et al.; IKEMA study group. Isatuximab, carfilzomib, and dexamethasone in relapsed multiple myeloma (IKEMA): a multicentre, open-label, randomised phase 3 trial. Lancet. 2021 Jun 19;397(10292):2361-2371. Doi: 10.1016/S0140-6736(21)00592-4.
- Cohen AD, Landau H, Scott EC, et al. Safety and efficacy of carfilzomib (CFZ) in previously-treated systemic light-chain (AL) amyloidosis. Blood 2016;128:645-645. Doi: 10.1182/blood.V128.22.645.645.
- Costa LJ, Davies FE, Monohan GP, et al. Phase 2 study of venetoclax plus carfilzomib and dexamethasone in patients with relapsed/refractory multiple myeloma. Blood Adv. 2021 Oct 12;5(19):3748-3759. doi: 10.1182/bloodadvances.2020004146.
- Jasielec JK, Kubicki T, Raje N, et al. Carfilzomib, lenalidomide, and dexamethasone plus transplant in newly diagnosed multiple myeloma. Blood 2020;136:2513-2523.
Appendix 1 – Covered Diagnosis Codes
ICD-10 |
ICD-10 Description |
C88.0 |
Waldenström macroglobulinemia |
C90.00 |
Multiple myeloma not having achieved remission |
C90.02 |
Multiple myeloma in relapse |
C90.10 |
Plasma cell leukemia not having achieved remission |
C90.12 |
Plasma cell leukemia in relapse |
C90.20 |
Extramedullary plasmacytoma not having achieved remission |
C90.22 |
Extramedullary plasmacytoma in relapse |
C90.30 |
Solitary plasmacytoma not having achieved remission |
C90.32 |
Solitary plasmacytoma in relapse |
E85.3 |
Secondary systemic amyloidosis |
E85.4 |
Organ-limited amyloidosis |
E85.81 |
Light chain (AL) amyloidosis |
E85.89 |
Other amyloidosis |
E85.9 |
Amyloidosis, unspecified |
Z85.79 |
Personal history of other malignant neoplasms of lymphoid, hematopoietic and related tissues |
Appendix 2 – Centers for Medicare and Medicaid Services (CMS)
The preceding information is intended for non-Medicare coverage determinations. Medicare coverage for outpatient (Part B) drugs is outlined in the Medicare Benefit Policy Manual (Pub. 100-2), Chapter 15, §50 Drugs and Biologicals. In addition, National Coverage Determinations (NCDs) and/or Local Coverage Determinations (LCDs) may exist and compliance with these policies is required where applicable. Local Coverage Articles (LCAs) may also exist for claims payment purposes or to clarify benefit eligibility under Part B for drugs which may be self-administered. The following link may be used to search for NCD, LCD, or LCA documents: https://www.cms.gov/medicare-coverage-database/search.aspx. Additional indications, including any preceding information, may be applied at the discretion of the health plan.
Medicare Part B Covered Diagnosis Codes (applicable to existing NCD/LCD/LCA): N/A
Medicare Part B Administrative Contractor (MAC) Jurisdictions |
||
Jurisdiction |
Applicable State/US Territory |
Contractor |
E (1) |
CA, HI, NV, AS, GU, CNMI |
Noridian Healthcare Solutions, LLC |
F (2 & 3) |
AK, WA, OR, ID, ND, SD, MT, WY, UT, AZ |
Noridian Healthcare Solutions, LLC |
5 |
KS, NE, IA, MO |
Wisconsin Physicians Service Insurance Corp (WPS) |
6 |
MN, WI, IL |
National Government Services, Inc. (NGS) |
H (4 & 7) |
LA, AR, MS, TX, OK, CO, NM |
Novitas Solutions, Inc. |
8 |
MI, IN |
Wisconsin Physicians Service Insurance Corp (WPS) |
N (9) |
FL, PR, VI |
First Coast Service Options, Inc. |
J (10) |
TN, GA, AL |
Palmetto GBA |
M (11) |
NC, SC, WV, VA (excluding below) |
Palmetto GBA |
L (12) |
DE, MD, PA, NJ, DC (includes Arlington & Fairfax counties and the city of Alexandria in VA) |
Novitas Solutions, Inc. |
K (13 & 14) |
NY, CT, MA, RI, VT, ME, NH |
National Government Services, Inc. (NGS) |
15 |
KY, OH |
CGS Administrators, LLC |